The Bayern Munich goalkeeper allowed a long-range free-kick by Real's Roberto Carlos to slip under his body in the Champions League first knockout phase match.
Manchester City came from behind to beat Club Brugge 3-1 and secure their place in the Champions League playoffs
Barcelona thrashed Real Betis 5-1 on Wednesday to book their spot in the Copa del Rey quarter-finals.
A round-up of Saturday's action in the English Premier League.
Man United get injury boost ahead of Liverpool FA Cup clash
In the third-tier Europa Conference League, English Premier League club Leicester City will face Danish side Randers and Scottish club Celtic will take on Norwegian champions Bodo/Glimt in the knockout playoff round.
Former Newcastle United goalkeeper Pavel Srnicek died on Tuesday at the age of 47, nine days after suffering a cardiac arrest in the CzechRepublic.
Arsenal goalkeeper Petr Cech was voted Czech Republic player of the year for 2015, the former Chelsea stopper picking up the award for a record eight time.
His overall record of five wins, two draws and seven defeats included shock losses to Hapoel Beer Sheva and Sparta Prague in the Europa League and at home to Cagliari in Serie A.
Former Bayern Munich coach Flick takes over Germany to 2024
Belgian league leaders Antwerp secured a shock 1-0 win over Tottenham Hotspur and AC Milan extended their unbeaten run to 23 games as they won 3-0 against Sparta Prague in the Europa League on Thursday, while Arsenal cruised to a 3-0 win over Dundalk.
Rennes denied late Europa League equaliser due to little-known rule
Juergen Klopp's Europa League nightmare came true on Friday when his Liverpool side was drawn to meet former club Borussia Dortmund in next month's quarter-finals.
Manchester United and Liverpool, English football's two most decorated clubs, were drawn together in the last 16 of the Europa League on Friday.
IMAGES from the Champions League matches played on Wednesday.
Liverpool added another fairytale comeback to the history books as they fought back from 3-1 down against Borussia Dortmund to reach the Europa League semi-finals after Dejan Lovren's towering stoppage-time header secured a 4-3 win on Thursday.
Sevilla's love affair with the Europa League was immediately rekindled as last season's champions and three-time winners began this year's group stage with a 2-0 home victory over Feyenoord on Thursday.
Harry Kane netted his 200th goal for Tottenham Hotspur as they won 3-1 at Ludogorets and AC Milan's 24-match unbeaten run ended
Inter Milan's aversion to Europa League football continued with a 3-1 defeat at Sparta Prague, while AS Roma ended a continental hoodoo stretching back seven games with a 4-0 home win over Romanian side FC Astra on Thursday.
Liverpool manager Juergen Klopp enjoyed a satisfying return to Borussia Dortmund as his new side frustrated his former charges and claimed a valuable away goal to draw 1-1 in their Europa League quarter-final, first leg on Thursday.
Romanians Astra handed West Ham United their first competitive defeat at the London Stadium as Slaven Bilic's team were beaten in the Europa League playoffs on Thursday.
Images from Europa League matches played on Thursday.
An impudent individual goal from Philippe Coutinho steered Liverpool comfortably into the quarter-finals of the Europa League on Thursday after a 1-1 draw at bitter rivals Manchester United completed a 3-1 aggregate win.
'We hit some unbelievable winners and nobody was clapping, so it's been really tough. But on the other hand it's nice to have the game-feeling again.'
Atletico de Kolkata's erratic run in away games continued as a spirited Pune City FC held them to a 1-1 draw in an 11th round encounter of the Indian Super League, in Pune, on Saturday.
Barcelona were held 1-1 at home by Napoli in the first leg of their Europa League knockout stage playoff
Arsenal might be struggling in the Premier League but they are 100 per cent in Group B of the Europa League
Napoli kept alive their hopes of advancing from Group C after Lorenzo Insigne, Victor Osimhen and Matteo Politano secured a 3-0 home win over Legia Warsaw.
Seven-time European champions AC Milan hit back from two goals down against Celtic to claim a 4-2 victory that sent them into the Europa League knockout phase on Thursday as they were among 14 teams to progress in Europe's second-tier competition.
PSG will need to rely on their attack against the team they knocked out in the semi-finals last season.
Images from action in the Europa League matches on Thursday.
An inspired Wayne Rooney became Manchester United's all-time leading goalscorer in European competition to ignite their crucial 4-0 trouncing of Feyenoord.
Tottenham Hotspur's Harry Kane pounced on a piece of comical defending to secure a 1-0 win over Sunderland in the Premier League on Sunday although he was later wheeled away on a stretcher after suffering an ankle injury.
Juergen Klopp got a taste of the problems at Liverpool as his first home game as manager ended in a frustrating 1-1 draw against Rubin Kazan who played more than 50 minutes with 10 men in the Europa League on Thursday.
United's Ibrahimovic, Roma's Dzeko find the net thrice to give clubs first leg advantage
A round-up of the weekend soccer action in eastern Europe.
Liverpool handed their fiercest rivals a painful lesson on Thursday with a dominant 2-0 win over Manchester United in the first leg of a Europa League last-16 clash.
Wayne Rooney's Everton homecoming ended in a 1-0 win over Slovak side Ruzomberok with the former Manchester United striker having a quiet return to Goodison Park in the Europa League, third qualifying round, first-leg on Thursday.
The value of an in-form striker was underlined as Tottenham Hotspur, Liverpool and Athletic Bilbao needed goals from pivotal front men to grab vital wins that booked places in the Europa League last 32 on Thursday.
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